Table 4. The modification of MBL2 haplotypes on risk of lung cancer due to childhood secondhand smoke.
| MBL2 Haplotype | NCI-MD study* | Mayo Clinic study | ||||
|---|---|---|---|---|---|---|
| Cases n (%) | Controls n (%) | OR (95% CI)† | Cases n (%) | Controls n (%) | OR (95% CI)† | |
| Exposed to childhood secondhand smoke | ||||||
| Medium MBL levels | 181 (63) | 89 (68) | 1.00 (reference) | 79 (81) | 104 (77) | 1.00 (reference) |
| LYQA | ||||||
| LYPA | ||||||
| Low MBL levels | 65 (23) | 33 (25) | 0.97 (0.59-1.58) | 8 (8) | 28 (21) | 1.06 (0.68-1.98) |
| LXPA | ||||||
| LYPB | ||||||
| HYPD | ||||||
| LYQC | ||||||
| High MBL levels | 41 (14) | 8 (6) | 2.52 (1.13-5.60) | 11 (11) | 3 (2) | 2.78 (1.18-3.85) |
| HYPA | ||||||
| No exposure to childhood secondhand smoke | ||||||
| Medium MBL levels | 38 (63) | 47 (73) | 1.00 (reference) | 56 (76) | 129 (84) | 1.00 (reference) |
| LYQA | ||||||
| LYPA | ||||||
| Low MBL levels | 15 (25) | 14 (22) | 0.57 (0.18-1.83) | 12 (16) | 20 (13) | 0.75 (0.40-1.66) |
| LXPA | ||||||
| LYPB | ||||||
| HYPD | ||||||
| LYQC | ||||||
| High MBL levels | 7 (12) | 3 (5) | 1.19 (0.18-7.79) | 6 (8) | 4 (3) | 1.05 (0.61-11.53) |
| HYPA | ||||||
*
Only 285 cases and 130 cases had complete MBL2 genotyping information available because of DNA degradation and since the study is ongoing some study participants were accrued after samples were sent for genotyping.
†
ORs are adjusted for age, gender, smoking status, exposure to adult secondhand smoke, education level, first-degree relative with lung cancer number of cigarettes/day (NCI-MD), number of years smoked (NCI-MD), age at initiation (NCI-MD), and time since quitting (NCI-MD).