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. Author manuscript; available in PMC: 2010 Oct 8.
Published in final edited form as: Cancer Cell. 2008 Nov 4;14(5):347–349. doi: 10.1016/j.ccr.2008.10.012

Figure 1. The Premetastatic Niche Is Similar to an Inflammatory Nidus.

Figure 1

Both S100A8 and S100A9 induce the expression of SAA3 specifically in future metastasis sites in the lung, promoting Mac1+ myeloid and endothelial cell engraftment. In this process, SAA3 promotes its own secretion by a positive feedback mechanism mediated by TLR4 and induces NF-κB signaling pathway activation (left). This inflammation-like state accelerates the future recruitment of tumor cells (right).