Table 3.
Regions active during inhibition ('nogo') trials for cocaine-exposed (A) and non-exposed children (B)
| Center of mass |
Center of intensity |
Lateralization | Size mm3 | |||||
|---|---|---|---|---|---|---|---|---|
| RL | AP | IS | RL | AP | IS | |||
| A. Cocaine-exposed children | ||||||||
| 1 anterior cingulate, cingulate gyrus | −1 | 32 | 13 | −3 | 33 | 3 | mid to left | 4,725 |
| 2 middle frontal gyrus, superior frontal gyrus, medial frontal gyrus | 21 | 53 | 10 | 27 | 60 | 12 | right | 3,537 |
| 3 insula, putamen | 35 | 17 | 19 | 33 | 15 | 24 | right | 1,971 |
| 4 caudate body, anterior nucleus, lateral globus pallidus, putamen | 11 | 1 | 12 | 6 | 0 | 9 | right | 1,917 |
| 5 insula, putamen | 34 | −3 | 6 | 39 | 0 | 9 | right | 1,404 |
| 6 parahippocampal gyrus, superior temporal gyrus, hippocampus | 33 | −28 | −12 | 30 | −27 | −15 | right | 1,080 |
| B. Non-cocaine-exposed children | ||||||||
| 1 fusiform gyrus, inferior occipital gyrus, insula, lingual gyrus, middle occipital gyrus | −18 | −79 | −4 | −18 | −99 | −12 | left | 16,983 |
| 2 fusiform gyrus, inferior occipital gyrus, lingual gyrus, middle occipital gyrus, cuneus | 30 | −89 | −7 | 27 | −84 | −18 | right | 7,128 |
| 3 insula, superior temporal gyrus, inferior frontal gyrus | −40 | 4 | 3 | −48 | 9 | −9 | left | 5,211 |
| 4 tuber, declive, culmen, dentate | 38 | −61 | −28 | 51 | −66 | −24 | right | 3,780 |
| 5 middle frontal gyrus, superior frontal gyrus, medial frontal gyrus | −24 | 48 | −1 | −24 | 51 | −12 | left | 2,241 |
| 6 insula, superior temporal gyrus, inferior frontal gyrus | 39 | 11 | −14 | 45 | 18 | −18 | right | 2,187 |
| 7 uncus, parahippocampal gyrus, superior temporal gyrus | −34 | −3 | −38 | −30 | 9 | −36 | left | 1,620 |
| 8 posterior cingulate, parahippocampal gyrus | −26 | −57 | 11 | −30 | −51 | 9 | left | 1,512 |
| 9 anterior cingulate | 6 | 35 | 13 | 0 | 33 | 12 | mid to right | 1,215 |
| 10 superior temporal gyrus, inferior frontal gyrus | −58 | 18 | 1 | −60 | 21 | 3 | left | 1,188 |
| 11 medial frontal gyrus | −6 | 45 | −14 | −3 | 45 | −21 | mid to left | 1,161 |
Clusters, with inclusive regions, in descending order by volume. RL = Right-left; AP = anterior-posterior; IS = inferior-superior.