Skip to main content
. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: ChemMedChem. 2010 Aug 2;5(8):1221–1225. doi: 10.1002/cmdc.201000186

Figure 3.

Figure 3

Compounds (+)-12 and (+)-18 normalize PCP-disrupted PPI in mice. Mice were administered (ip) saline or 6 mg/kg PCP and immediately tested for PPI of the acoustic startle response. (A) and (B). 30 min pre-treatments of mice with (+)-12 or (+)-18 effectively normalize PCP-disruption of PPI. (C). Compound 3, a positive reference control compound, also normalizes PCP-disrupted PPI. *, p < 0.05 versus saline treated animals. Data are the mean ± SEM. N = 9, 10 or 7 animals in each testing group for (+)-12, (+)-18 or 3, respectively.