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. 2010 Oct 5;6:667–679. doi: 10.2147/NDT.S12612

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© 2010 Canuso et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Adjusted mean differences and 95% confidence intervals for total YMRS and HAM-D-21 change scores at endpoint with paliperidone ER versus placebo in patients with manic or depressive symptoms at baseline (intent-to-treat analysis set).

Notes: Analysis is based on an ANCOVA model with fixed effects for treatment, study, country nested within study, and the baseline value as a covariate. ^aP ≤ 0.001, paliperidone ER versus placebo; ^bP < 0.05, paliperidone ER versus placebo.

Abbreviations: CI, confidence interval; ER, extended-release; HAM-D-21, 21-item Hamilton Rating Scale for Depression; LS, least-squares; MS/ADs, mood stabilizers/ antidepressants; PANSS, Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale.