Table 1.

Quantitative analysis of cortical cholinergic depletion following site-specific cholinergic lesions

		Cholinergic depletion (% loss relative to intact)
		PFC	Motor cortex	AUD
Targeted lesion site	PFC	93.7 ± 3.0***	7.5 ± 9.1	ND
	Motor cortex	9.5 ± 5.5	98.7 ± 0.6***	20.2 ± 7.6*
	AUD	14.0 ± 3.6*	−4.9 ± 4.3	98.1 ± 1.2***
	Global	85.3 ± 2.4***	99.7 ± 0.3***	100 ± 0.0***

Note: Values in the table represent the percentage loss in innervation relative to vehicle-treated (intact) controls. Site-specific injections of the immunotoxin within the cortical parenchyma reduce cholinergic innervation to a level comparable with that seen following global depletion but only within the region targeted by the lesion. In most cases, cortical sites not targeted by the lesion showed no significant loss of cholinergic innervation density. *P < 0.05; ***P < 0.001; ND: not determined.