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. 2010 Jun 3;116(12):2078–2088. doi: 10.1182/blood-2010-02-271171

Figure 5.

Figure 5

CAL-101 induces apoptosis more selectively than pan-PI3K inhibitors. (A) CD19+ cells from patients with CLL (n = 49) were incubated with or without 10μM CAL-101 or 25μM LY294002 for 48 hours. Viability was determined by annexin/PI flow cytometry and is shown relative to time-matched untreated controls. Horizontal lines represent the mean. (B) CD19+ B cells, CD3+ T cells, and CD56+ NK cells (n = 10; each) were incubated with or without 10μM CAL-101 and 25μM LY294002 for 48 hours. Viability was determined by annexin/PI flow cytometry and is shown relative to time-matched untreated controls. Error bars represent the SD from the mean.