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. 2010 Aug 17;19(21):4253–4264. doi: 10.1093/hmg/ddq348

Figure 5.

Figure 5.

Kismet is required for proper axon pruning and axon migration in developing mushroom bodies. All panels show GFP in Kenyon neurons by MARCM analysis. (A and B) Pupal brains 18–20 h after puparium formation (apf). (C and D) Adult brains 48 h after eclosion. (A) Wild-type MARCM clones (FRT 40A) in pupal brains driven by 201Y-Gal4 show remnants of proper axonal pruning of γ neurons that were previously populating the α lobes (arrow). (B) kisLM27 homozygous mutant MARCM clones display unpruned γ axons that continue to populate the α lobes (arrow). (C) Wild-type MARCM clones (FRT 40A) in adult brains driven by OK107-Gal4 show normal pattern of α, α′, β, β′ and γ axons innervating the mushroom body lobes, as labeled. (D) kisLM27 homozygous mutant MARCM clones in these adult brains often display abnormal axon migration beyond the midline (demarcated by the arrowhead).