TABLE 1.

CYTOKINE PROFILES IN BRONCHOALVEOLAR LAVAGE FLUID AFTER EXPOSURE FOR 6 HOURS/DAY TO 25 ppm NO2 FOR 3 DAYS

	Air		NO2
	WT	CC10-IκBαSR	WT	CC10-IκBαSR
IL-6	0	0.2 ± 0.1	8.2 ± 2.9*	0.9 ± 0.6†
IL-9	1.5 ± 0.9	4.9 ± 1.0	4.2 ± 0.8*	2.1 ± 0.4†
IL-12 (p40)	38.4 ± 12.7	22.8 ± 1.8	114.2 ± 21.5*	86. 2 ± 22.1†
G-CSF	0.7 ± 0.4	0.7 ± 0.2	14.7 ± 4.3*	7.0 ± 2.4†
KC	0.6 ± 0.1	0.2 ± 0.1	7.3 ± 1.2*	1.2 ± 0.1†
MCP-1	0	0.5 ± 0.5	31.4 ± 8.2*	14.5 ± 2.6†
RANTES	0.1 ± 0.04	0.1 ± 0.05	0.5 ± 0.1*	0.2 ± 0.1†

Definition of abbreviations: G-CSF, granulocyte colony–stimulating factor; KC, keratinocyte-derived chemoattractant; MCP-1, macrophage chemotactic protein; RANTES, regulated upon activation normal T cell expressed and presumably secreted; WT, wild-type.

Concentrations of IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-10, IL-12 (p70), IL-13, IL-17, GM-CSF, MIP-1α, eotaxin, TNF-α, and IFN-γ were below the limits of detection in all samples. Concentrations of MIP-1β were within the limits of detection, but were not different between groups. Data represent cytokine levels in pg/ml, and are expressed as mean ± SEM from 4–6 mice/group.

^*P ≤ 0.05 compared with WT mice exposed to air.

^†P ≤ 0.05 compared with WT mice exposed to NO₂.