Figure 1.

Allergen challenge of passively sensitized guinea pigs elicits airway inflammation and remodeling. Compared with control tracheas (A), eosinophils (arrows) were increased in the trachea 24 (B, arrows) and 48 hours (data not shown) after a single allergen challenge. (C) Summary of the effects of single allergen challenges (groups A and B) on eosinophil density. Eosinophils were also increased 24 hours (data not shown) and 48 hours (D, arrows) after a second allergen challenge. Also common with chronic allergen challenge, there was disruption of the epithelial layer lining the lower airways 48 hours after a second allergen challenge (arrowheads in D). Scale bar in D is for images in A, B, and D. Asterisks in C signify differences in the number of eosinophils in treated tissue as compared with control.