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. 2009 Nov 13;43(4):465–474. doi: 10.1165/rcmb.2009-0211OC

Figure 4.

Figure 4.

STAT phosphorylation in the human tuberculous granuloma. (Ai) Hematoxylin and eosin section demonstrating fibrotic granuloma. (Aii) STAT1 phosphorylation. Samples were used as in Figure 2D. STAT1 (nickel; black) phosphorylation (arrowed) was readily demonstrated throughout the granuloma, and co-localized mainly with CD68-positive cells (alkaline phosphatise; red). (Bi and Bii) Phosphorylated STAT3 Tyr 705 (black stain). Phosphorylated STAT Tyr 705 was identified in some of the CD68-positive cells in the granuloma (hollow arrow) in a nuclear staining pattern, but mainly was localized to the peripheral spindle-shaped CD68 negative cells (solid arrow). (Ci and Cii) Phosphorylated STAT3 Ser727 was also found in both CD68-positive cells (hollow arrow) and in the peripheral spindle-shaped CD68-negative cells (solid arrow). Scale bar indicates 50 μm.