Figure 2.
Effect of LPS+MV on alveolar permeability. (A) Total protein and (B) IgM were measured in the bronchoalveolar lavage fluid from adult and juvenile mice treated with inhaled LPS, MV, and LPS+MV. Values are mean ± SD (n = 10 per group). ‡Additive effect of LPS and MV in adult mice (P = 0.13). §Significant decrease in protein in juvenile mice treated with LPS+MV as compared with the effects of LPS or MV alone (P = 5.3 × 10−9). Asterisk and diamond indicate the effects of age on the responses to MV and LPS+MV, respectively (P = 6.0 × 10−7 and P = 1.1 × 10−5). †Synergism between LPS and MV in adult mice (P = 0.030). The circle indicates the effect of age on the response to LPS+MV (P = 0.011).