Skip to main content
. Author manuscript; available in PMC: 2010 Oct 8.
Published in final edited form as: Am J Physiol Endocrinol Metab. 2008 Feb 12;294(4):E709–E718. doi: 10.1152/ajpendo.00662.2007

Fig. 5.

Fig. 5

IL-1β-induced expression of IL-6 is inhibited by an ERK1/2 but not by a JNK antagonist. C2C12 myoblasts were incubated with PD98059 and SP600125 (10 µM) at a concentration that inhibits ERK1/2 and JNK activation, respectively (10 µM, data not shown), 1 h before treatment with IL-1β (1 ng/ml). IL-1β increased expression of IL-6 (n = 3). This IL-1β-induced increase in IL-6 concentration was significantly impaired by preincubation with the ERK1/2 inhibitor PD98059 but not by the JNK inhibitor SP600125. **P < 0.01.