Table 2. Lesion detected in CML samples by SNP array analysis.
Patients ID | Chromosome | Genic status | Starting position | Ending position | Genes identified | Disease status | Response to imatinib |
R01C02 | 5 | Del | 81629356 | 115815122 | LOC92270 | BC | Resistance |
R01C02 | 9 | Del | 127196469 | 132665560 | FREQ,CDK9 | BC | Resistance |
R01C02 | 22 | Del | 22053721 | 22902745 | GSTTP1, LOC388882, IGLL1, C22orf16, MMP11, SLC2A11, MIF, FLJ31568 | BC | Resistance |
R01C02 | 22 | Dup | 23995985 | 24240879 | LRP5L, ADRBK2 | BC | Resistance |
R06C01 | 7 | Del | 61862616 | 61921953 | No gene | CP | Resistance |
R06C01 | 19 | Dup | 32493654 | 33528102 | LOC727780,LOC642290,LOC727771 | CP | Resistance |
R02C01 | 11 | Del | 50354779 | 51228612 | OR4A5, LOC646813 | CP | Resistance |
R02C01 | 19 | Del | 20423788 | 20514068 | LOC645490 | CP | Resistance |
R04C01 | 11 | Del | 46327343 | 47374448 | F2,SPI1,DGKZ,AMBRA1,MADD C11orf49,PACSIN3 | BC | Resistance |
R04C01 | 17 | Del | 44176361 | 52843822 | >20 genes | BC | Resistance |
R04C01 | 2 | LOH | 78822450 | 89733531 | >20 genes | BC | Resistance |
R04C01 | 2 | LOH | 98364441 | 109797238 | >20 genes | BC | Resistance |
R04C01 | 2 | LOH | 109809150 | 121111631 | >20 genes | BC | Resistance |
R04C01 | 3 | LOH | 142389922 | 153466638 | >20 genes | BC | Resistance |
R04C01 | 5 | LOH | 156922335 | 168529461 | >20 genes | BC | Resistance |
R04C01 | 15 | LOH | 82248349 | 100215359 | >20 genes | BC | Resistance |
R04C01 | 20 | LOH | 29310063 | 55040991 | >20 genes | BC | Resistance |
R03C02 | 1 | Del | 240744201 | 241169492 | LOC391183, PLD5 | CP | Sensitivity |
Starting position: start position of genomic lesion; Ending position: end position of genomic lesion;LOH: loss of heterozygosity, Del; deletion, Dup; duplication.BC,blast crisis; CP, chronic-phase.