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. 2010 Oct 8;5(10):e13186. doi: 10.1371/journal.pone.0013186

Table 2. Lesion detected in CML samples by SNP array analysis.

Patients ID Chromosome Genic status Starting position Ending position Genes identified Disease status Response to imatinib
R01C02 5 Del 81629356 115815122 LOC92270 BC Resistance
R01C02 9 Del 127196469 132665560 FREQ,CDK9 BC Resistance
R01C02 22 Del 22053721 22902745 GSTTP1, LOC388882, IGLL1, C22orf16, MMP11, SLC2A11, MIF, FLJ31568 BC Resistance
R01C02 22 Dup 23995985 24240879 LRP5L, ADRBK2 BC Resistance
R06C01 7 Del 61862616 61921953 No gene CP Resistance
R06C01 19 Dup 32493654 33528102 LOC727780,LOC642290,LOC727771 CP Resistance
R02C01 11 Del 50354779 51228612 OR4A5, LOC646813 CP Resistance
R02C01 19 Del 20423788 20514068 LOC645490 CP Resistance
R04C01 11 Del 46327343 47374448 F2,SPI1,DGKZ,AMBRA1,MADD C11orf49,PACSIN3 BC Resistance
R04C01 17 Del 44176361 52843822 >20 genes BC Resistance
R04C01 2 LOH 78822450 89733531 >20 genes BC Resistance
R04C01 2 LOH 98364441 109797238 >20 genes BC Resistance
R04C01 2 LOH 109809150 121111631 >20 genes BC Resistance
R04C01 3 LOH 142389922 153466638 >20 genes BC Resistance
R04C01 5 LOH 156922335 168529461 >20 genes BC Resistance
R04C01 15 LOH 82248349 100215359 >20 genes BC Resistance
R04C01 20 LOH 29310063 55040991 >20 genes BC Resistance
R03C02 1 Del 240744201 241169492 LOC391183, PLD5 CP Sensitivity

Starting position: start position of genomic lesion; Ending position: end position of genomic lesion;LOH: loss of heterozygosity, Del; deletion, Dup; duplication.BC,blast crisis; CP, chronic-phase.