Table 2. CSF metabolite profiles in ALS and control subjects measured by ¹H NMR spectroscopy.

Metabolites (µmol/L)	ALS (n = 50)	Non ALS (n = 44)	p
AHBT	61 (0–137)	59 (0–177)	0.17
Ethanol	24 (0–170)	24 (0–460)	0.29
Alanine	56 (6–596)	61 (0–214)	0.74
Acetate	53 (9–389)	104 (2–366)	0.0002
BHBT	17 (4–85)	27 (0–134)	0.97
Lactate	2076 (444–3892)	2020 (94–5322)	0.81
Acetoacetate	9 (0–29)	8 (0–29)	0.89
Acetone	11 (0–59)	5 (0–23)	0.015
Glutamine	716 (139–1272)	785 (35–1296)	0.24
Pyruvate	68 (3–128)	17 (0–201)	0.002
Citrate	283 (22–49)	285 (12–754)	0.51
Creatine/creatinine	155 (25–316)	160 (9–450)	0.65
Glucose	3240 (560–7166)	3174 (150–8928)	0.98
Fructose	428 (0–1224)	419 (0–967)	0.82
Ascorbate	25 (0–152)	0 (0–165)	0.003
Tyrosine	12 (0–48)	8 (0–117)	0.35
Formate	28 (3–91)	30 (1–187)	0.35

Data are expressed in median and range. P value inferior to threshold after correction for multiple test (p = 0.003) are shown in bold.

AHBT: Alphahydroxybutyrate.

BHBT: Betahydroxybutyrate.