. 2010 Oct 8;5(10):e13236. doi: 10.1371/journal.pone.0013236

Table 1. Clinical and biological criteria for severe malaria according to the 2000 World Health Organization definition with modifications (see ^* and ^†).

Clinical criteria

Impaired consciousness: Glasgow Coma Scale score <11^*

Respiratory distress: requirement for noninvasive and/or endotracheal mechanical ventilation or spontaneous breathing with PaO₂ <60 mm Hg (if FiO₂ ≥0.21) ^†, and/or respiratory rate >32/min^*

Multiple convulsions

Circulatory collapse: systolic blood pressure <80 mm Hg despite adequate volume repletion

Abnormal bleeding

Jaundice: clinical jaundice or bilirubin >50 µmol/L

Macroscopic hemoglobinuria: if unequivocally related to acute malaria (patients with blackwater fever were not included)

Laboratory criteria

Severe anemia: hemoglobin <5 g/dL

Hypoglycemia: blood glucose <2.2 mmol/L

Acidemia (pH<7.35) or acidosis (serum bicarbonate <15 mmol/L)

Hyperlactatemia: arterial lactate >5 mmol/L

Hyperparasitemia ≥4%

Renal impairment: serum creatinine >265 µmol/L or blood urea nitrogen >17 mmol/L^*

*Coma scale criteria of 11 instead of 9; respiratory rate >32/minute and blood urea nitrogen > 17 mmol/L are modifications according to the SEAQUAMAT group [8].

^†

The requirement for noninvasive and/or endotracheal mechanical ventilation or spontaneous breathing with PaO₂ <60 mm Hg (if FiO₂ ≥0.21) was used specifically for this study.

Table 1. Clinical and biological criteria for severe malaria according to the 2000 World Health Organization definition with modifications (see * and †).

Table 1. Clinical and biological criteria for severe malaria according to the 2000 World Health Organization definition with modifications (see ^* and ^†).