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MMP-8 processing of murine (A) and human (B) IL-10 in vitro. Cleavage results in a 14 kDa fragment in addition to intact IL-10 (18 kDa). In vivo cleavage (C) also occurs. Although there is a 14 kDa fragment in both genotypes, indicating overlapping of other proteases, the percentage of intact IL-10 is significantly higher (*p<0.05) in knockout mice (D), demonstrating the relevance of MMP-8 in IL-10 metabolism in vivo.
