Table 1.
Response to empirical treatment criteria applied at 8-week visit (modified from Wilson26)
| Response criteria | Definition of response (compared to baseline) |
|---|---|
| Smear conversion | Change from positive to negative |
| Body weight | Increase of 5% |
| Haemoglobin | Increase of at least 1.0 g/dl |
| C-reactive protein | Decrease of at least 70% |
| Karnofsky performance index | Increase of at least 20 points (or 10 points if baseline was ≥ 80) |
| Symptom count ratio (number of symptoms improved or resolved, divided by number of symptoms at baseline. Symptoms from predefined list of acceptable symptoms) | Improvement or resolution of at least 50% of symptoms |