Table 2.
Association between markers in CAPN10 gene and pancreatic cancer using conditional logistic regression, assuming additive genetic models, based on cases (N=83) and matched controls (N=166) in the CARET cohort
| Individual SNPs and three-marker haplotype | ||||||
| SNP | Minor allele | MAF (case/control) | OR | 95%CIa | p value | |
| SNP-44 | C | (0.18/0.11) | 1.69 | (0.99-2.91) | 0.055 | |
| SNP-43 | A | (0.35/0.26) | 1.57 | (1.03–2.38) | 0.035 | |
| Indel-19 | del | (0.41/0.36) | 1.31 | (0.86–1.99) | 0.203 | |
| SNP-63 | T | (0.11/0.11) | 1.00 | (0.53–1.90) | 1.000 | |
| Three-marker haplotypea | Frequency | OR | 95% CI | p value | ||
| TG-ins | 0.58 | 1 | (reference) | |||
| CG-ins | 0.14 | 1.98 | (1.12–3.49) | 0.019 | ||
| TA-ins | 0.28 | 1.78 | (1.15–2.80) | 0.010 | ||
| Interaction by diabetes status | ||||||
| SNP | Minor allele | With diabetes | Without diabetes | p value for the interaction | ||
| OR | 95% CI | OR 95%CI | ||||
| SNP-44 | C | 1.77 | (0.25–12.69) | 1.59 | (0.89–2.85) | 0.878 |
| SNP-43 | A | 1.39 | (0.34–5.69) | 1.61 | (1.00–2.59) | 0.754 |
| Indel-19 | del | 1.83 | (0.36–9.32) | 1.20 | (0.77–1.86) | 0.481 |
| SNP-63 | T | 3.40 | (0.13–87.0) | 0.92 | (0.78–1.77) | 0.307 |
| Three-marker haplotypea | ||||||
| TG-ins | 1 | (reference) | 1 | (reference) | 0.906 | |
| CG-ins | 2.53 | (0.31–20.7) | 1.87 | (1.02–3.46) | ||
| TA-ins | 1.76 | (0.39–8.02) | 1.82 | (1.11–3.01) | ||
OR odds ratio, risk per copy of the minor allele, 95%CI 95% confidence interval, indel insertion/deletion, ins insertion, MAF minor allele frequency
a
Three-marker haplotypes formed by SNP-44, SNP-43, and Indel-19 (rs2975760, rs3792267, and rs3842570)