Table 2.
Univariate Associations between selected risk factors and baseline plasma Hcy
| Characteristic† | Baseline Plasma Homocysteine μmol/L‡ | ||||
|---|---|---|---|---|---|
| ≤ 7.95 | 7.96-9.26 | 9.27-11.25 | > 11.25 | P * | |
| Age mean (SD) | 54.6 (9.3) | 58.1 (9.1) | 58.4 (9.6) | 58.9 (9.7) | <0.001 |
| Male (%) | 41.0 | 62.2 | 76.9 | 77.7 | <0.001 |
| Current smoker (% yes) | 12.2 | 11.7 | 11.9 | 21.0 | 0.01 |
| BMI (kg/m2) % /category 1 (≤ 25 kg/m2) 2 (25 - < 30 kg/m2) 3 (≥ 30 kg/m2) |
37.8 38.7 23.4 |
34.7 43.2 22.1 |
25.1 49.3 25.6 |
23.8 54.7 21.5 |
0.01 |
| Alcohol drinker (% yes) | 62.0 | 70.1 | 67.7 | 73.9 | 0.06 |
| Alcohol mean (SD) drinks /d among drinkers |
0.6 (0.8) | 0.9 (1.3) | 0.9 (0.9) | 1.2 (1.4) | <0.001 |
| Baseline Plasma Folate nmol/L mean (SD) |
31.0 (18.5) | 26.2 (16.6) | 20.7 (14.0) | 17.3 (17.6) | <0.001 |
| Baseline Plasma B12 pmol /L mean (SD) |
371 (145) | 346 (210) | 309 (113) | 295 (163) | <0.001 |
| Baseline Plasma B6 nmol/L mean (SD) | 107 (118) | 84 (87) | 73 (84) | 61 (57) | <0.001 |
| Baseline Plasma B2 nmol/L mean (SD) | 36 (50) | 33 (61) | 27 (51) | 24 (43) | <0.001 |
| Number of adenomas at baseline exam mean (SD) |
1.4 (0.8) | 1.5 (0.8) | 1.7 (1.2) | 1.7 (1.0) | 0.001 |
| MTHFR 677 C>T Genotype (% yes) CC CT TT |
49.5 44.1 6.4 |
45.2 42.9 12.0 |
49.0 40.4 10.6 |
37.9 50.0 12.1 |
0.11 |
†
All risk factor values were taken from the baseline questionnaire.
‡
Quartile cutpoints based on the distribution of plasma tHcy in the whole study population.
*
P for trend for continuous variables (age, number of alcohol drinks, plasma levels, number of baseline adenomas) or p for heterogeneity for categorical variables (sex, current smoker, BMI, alcohol drinker, MTHFR 677).