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. Author manuscript; available in PMC: 2011 Apr 3.
Published in final edited form as: Nat Med. 2010 Oct 3;16(10):1117–1119. doi: 10.1038/nm.2233

Fig. 1. Matched-IgG, but not Mismatched-IgG, affects plasma viral load in SHIVSF162P3-infected infant macaques.

Fig. 1

Neutralizing activity of Matched IgG, with IgG1-b12 (■) and without IgG1-b12 (□), and Mismatched IgG (●) against: the challenge virus SHIVSF162P3 (a) and heterologous virus SHIV89.6P (b). Vertical line at 2 × 103 denotes the estimated in vivo passive IgG concentration of 2 mg ml−1. (c) Mean PBMC proviral loads during the 24 weeks after initiation of infection as quantified by real-time PCR. (d) Mean plasma viral loads as quantified by real-time PCR during the 24 weeks after initiation of infection. (e) Differences in AUC comparing Normal-IgG, Mismatched-IgG, and Matched-IgG for the entire 24 weeks. (f) Differences in AUC calculations for post-acute viremia between all treatment groups (weeks 8–24). Horizontal bar indicates the median value for the group. P values are indicated.