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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Arthritis Rheum. 2010 Oct;62(10):2909–2918. doi: 10.1002/art.27594

Figure 4.

Figure 4

T cell responses to citrullinated peptides. A) Tetramer staining of cultured CD4+ T cells from two RA subjects with DR1001 haplotype and one HLA-matched healthy control subject with citrullinated or unmodified sequences (as labeled). Tetramer positive populations more than 0.5% above background were considered positive (underlined). B) Tetramer staining of representative T cell clones specific for citrullinated sequences from joint associated proteins. C) Proliferation of T cell clones in response to citrullinated (closed bars) or unmodified (open bars) peptide sequences. The dashed line indicates background proliferation (512 CPM).