Table 1.
Motif Analysis for Novel and Published DR1001 Epitopes
| Peptide | Sequence* | Pred. RBA |
|---|---|---|
| NP 73-92 | ERRNKYLEEHPSAGKDPKKT | 0.21 |
| NP 305-324 | RLLQNSQVYSLIRPNENPAH | 0.20 |
| MP 41-60 | VLMEWLKTRPILSPLTKGIL | 0.35 |
| MP 97-116 | VKLYRKLKREITFHGAKEIS | 0.02 |
| HA HK 169-188 | ATNSLTIEVPYICTEGEDQI | 0.05 |
| HA Pan 97-116 | CYPYDVPDYASLRSLVASSG | 0.13 |
| HA Pan 297-316 | VNRITYGACPRYVKQNTLKL | 0.07 |
| HA Pan 305-324 | CPRYVKQNTLKLATGMRNVP | 0.07 |
| HA Pan 313-332 | TLKLATGMRNVPEKQTRGIF | 0.01 |
| HA NC 201-220 | IGNQRALYHTENAYVSVVSS | 1.3 |
| HA NC 217-236 | VVSSHYSRRFTPEIAKRPKV | 2.0 |
| TT 482-501 | NSFSEEPFQDEIVSYNTKNK | 0.45 |
| TT 554-573 | NIDDNTIYQYLYAQKSPTTL | 2.0 |
| PA 449-468 | ALNAQDDFSSTPITMNYNQF | 0.05 |
| PA 465-484 | YNQFLELEKTKQLRLDTDQV | 0.04 |
| PA 585-604 | QQTSQNIKNQLAELNATNIY | 0.25 |
| MP1 17-29 | SGPLKAEIAQRLE | 0.18 |
| HA1 255-270 | RGYFKMRTGKSSIMRS | 0.24 |
| HDV 50-65 | WLGNIKGILGKKDKDG | 0.13 |
| PTPRK 670-682 | PYYFAAELPPRNLPEP | 0.52 |
*
Predicted binding registers indicated in boldface secondary registers underlined
NP: Influenza A/Puerto Rico/8/34 Nucleoprotein (novel epitopes)
MP: Influenza A/Puerto Rico/8/34 Matrix Protein M1 (novel epitopes)
HA HK: Influenza B/Hong Kong/330/2001 Hemagglutinin (novel epitopes)
HA Pan: Influenza A/Panama/2007/99 Hemagglutinin (novel epitopes)
HA NC: Influenza A/New Caledonia/20/99 Hemagglutinin (novel epitopes)
TT: Tetanus Toxin Heavy Chain (novel epitopes)
PA: Antrax protective antigen (novel epitopes)
MP1: Matrix Protein (ref. 28)
HA1: Hemagglutinin (ref. 29)
HDV: Hepatitis Delta Virus (ref. 30)
PTPRK: Melanoma antigen (ref. 31)