Table 2.

In Vitro Binding of Citrullinated Peptides from Joint Associated Proteins

Peptide	Sequence*	IC50
Vimentin 58-72	GGVYATRSSAVRLRS	>100
	GGVYATXSSAVXLRS	23
Fib A 24-38	EGDFLAEGGGVRGPR	>100
	EGDFLAEGGGVXGPR	>100
Fib A 383-397	TGQWHSESGSFRPDS	>100
	TGQWHSESGSFXPDS	>100
Fib A 506-520	LDGFRHRHPDEAAFF	>100
	LDGFRHXHPDEAAFF	>100
Fib A 737-751	YAEYHFRVGSEAEGY	>100
	YAEYHFXVGSEAEGY	39
Fib B 68-82	GGGYRARPAKAAATQ	>100
	GGGYRAXPAKAAATQ	14
Fib G 217-231	WTVFQKRLDGSVDFK	>100
	WTVFQKXLDGSVDFK	>100
CILP 538-552	VLTFVDRLQKFVNTT	>100
	VLTFVDXLQKFVNTT	>100
CILP 738-751	ERRLFNLDVPESRR	0.4
	ERRLFNLDVPESXR	0.6
CILP 982-996	GKLYGIRDVRSTRDR	13
	GKLYGIXDVXSTRDR	2.8
Filag 2116-2130	GSHYDQAQDSSRHSA	>100
	GSHYDQAQDSSXHSA	>100
α Enolase 9-23	REIFDSRGNPTVEVD	>100
	REIFDSXGNPTVEVD	>100

^*Predicted binding register underlined with anchor residues in boldface. X = citrulline