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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2010 May 7;18(13):4801–4811. doi: 10.1016/j.bmc.2010.05.001

Figure 1.

Figure 1

Panel A: GDC0449 (1) and HhAntag (2) are inhibitors of Smo, and GANT61 (3) and Physalin (4) are inhibitors of Gli-mediated transcription. Panel B: Inhibitors of Gli1-mediated transcription (5 and 6) and lead optimization in this study.