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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2010 May 7;18(13):4801–4811. doi: 10.1016/j.bmc.2010.05.001

Scheme 1.

Scheme 1

(a) HBTU (for 20–31) or HATU (for 32–39 and 42–44), N,N-diisopropylethylamine, DMF, room temperature; (b) R2Br, DMF, microwave, 5 min, 150 °C. Compound 8 was previously prepared from ketoprofen 7.10