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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2010 May 7;18(13):4801–4811. doi: 10.1016/j.bmc.2010.05.001

Figure 2.

Figure 2

Replacement of the phenol in 5 with an indole moiety afforded equipotent inhibition of Gli1-mediated transcription. Percent inhibition of Gli-responsive firefly luciferase reporter activity in Gli1-transfected C3H10T1/2 cells 24 h after addition of 10 µM (open bar) or 20 µM (closed bar) of the test compound. Each Gli-Luc firefly luciferase signal is normalized with a Renilla luciferase transfection control and the normalized Gli-Luc activity with DMSO treatment serves as 0% inhibition. Error bars represent standard error of triplicate data.