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. 2010 Jul-Aug;3(4):266–274. doi: 10.4161/oxim.3.4.12859

Figure 1.

Figure 1

Effect of ifosfamide (IFO) on the levels of total carnitine in serum (A), total carnitine in cardiac tissues (B) and ATP concentration in cardiac tissues (C) from propionyl-l-carnitine (PLC)-supplemented and carnitine-depleted rats. Rats were randomly divided into 6 different groups of 10 animals each: Control, D-carnitine-mildronate (DC-MD, carnitine-depleted group), PLC (carnitine supplemented group), IFO, DC-MD plus IFO and PLC plus IFO. Carnitine depletion was induced in rats by daily intraperitoneal injection of DC (250 mg/kg/day) combined with MD (200 mg/kg/day) for 10 successive days. Carnitine supplementation was induced in rats by daily intraperitoneal injection of PLC (250 mg/kg/day) for 10 successive days. Fanconi Syndrome was induced in rats by administration of IFO (50 mg/kg/day, I.P.) for 5 successive days. IFO-carnitine depleted rats were given the same doses of DC-MD for 5 days before and 5 days concomitant with IFO. IFO-carnitine supplemented rats were given the same doses of PLC for 5 days before and 5 days concomitant with IFO. At the end of the treatment protocol, total carnitine was measured in serum whereas ATP and total carnitine were measured in cardiac tissues. Data are presented as mean ± S.E.M. (n = 10). *, # and $ indicate significant change from control, IFO and DC-MD respectively, at p < 0.05 using ANOVA followed by Tukey-Kramer as a post ANOVA test.