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. 2010 Mar-Apr;3(2):122–128. doi: 10.4161/oxim.3.2.6

Figure 3.

Figure 3

(A) Measurement of B-cell activators interleukin (IL)-6 and IL-13 in bronchoalveolar lavage (BAL) from patients with Behçet disease (BD) with pulmonary manifestations. IL-6 and IL-13 levels were performed with cytometric bead array (CBA) assay as reported in materials and methods. Increased levels of IL-6 and IL-13 were observed between BD patients and healthy controls (p = 0.0001). This result indicated an expanded production of inflammatory mediators in BAL from BD patients with pulmonary manifestation. Collectively, these data suggest that local production of the B cell-stimulating cytokines BAFF, IL-13 and IL-6 might play a role in local B-cell responses, in the lower airways of patients with BD. (B) Correlations between B cell-activating factor (BAFF) (pg/ml) and interleukin (IL-6) levels in bronchoalveolar lavage (BAL) fluid. Correlation was assessed with the spearman rank correlation. Significant correlation was obtained between BAFF and IL-6 levels (r = 0.882; p < 0.001) in Behçet disease (BD). (C) Correlations between B cell-activating factor (BAFF) (pg/ml) and interleukin (IL-13) (pg/ml) levels in bronchoalveolar lavage (BAL) fluid. Correlation was assessed with the Spearman rank correlation. Significant correlation was obtained between BAFF and IL-13 levels (r = 0.659; p < 0.001) in Behçet disease (BD).