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Continuous infusion of nicotinamide (NAM) significantly elevated serum NAM but not NAD+ levels following cortical contusion injury (CCI). Plotted are the mean (+SE M) blood serum levels (µg/mL) of NAM and NAD+ determined by HP LC for the NAM-treated, vehicle-treated, and sham animals collected following 7 days of continuous infusion of NAM (50 mg/kg/day, s.c. minipump). NAM was significantly elevated (*p < 0.05) compared to vehicle; whereas, NAD+ levels were only slightly elevated.
