Figure 4.

Continuous infusion of nicotinamide (NAM) significantly improved recovery on the forelimb asymmetry test following cortical contusion injury (CCI). The graph shows the plotted mean (+SEM) of the percent forelimb bias for all three experimental groups (NAM-treated, vehicle-treated and sham) following unilateral CCI. The no bias line indicates the point at which the ipsilateral and contralateral forelimbs are being used equally. Seven days of continuous infusion of NAM significantly improved performance compared to vehicle. Although, a significant treatment effect was seen with NAM compared to vehicle in the injured animals, there were still enduring deficits compared to the sham controls.