Table 1.
Respiratory parameters during hydrogen sulfide donor NaHS infusion and induced hypothermia in a mechanically ventilated model of ventilator-induced lung injury (VILI), at baseline (T = 0) and after 4 h of mechanical ventilation (T = 4)
| Time (h) | LP | VILI | |||||
|---|---|---|---|---|---|---|---|
| Saline | NaHS | Hypothermia | Saline | NaHS | Hypothermia | ||
| pH | T = 0 | 7.33 ± 0.14 | 7.38 ± 0.07 | 7.43 ± 0.08 | 7.47 ± 0.07 | 7.41 ± 0.06 | 7.47 ± 0.05 |
| T = 4 | 7.28 ± 0.14 | 7.41 ± 0.03 | 7.36 ± 0.09 | 7.46 ± 0.06 | 7.42 ± 0.10 | 7.43 ± 0.11 | |
| PaCO2 (kPa) | T = 0 | 5.3 ± 1.5 | 5.4 ± 1.0 | 4.6 ± 0.4 | 4.2 ± 0.6 | 5.0 ± 0.7 | 4.0 ± 0.8 |
| T = 4 | 6.0 ± 1.7 | 4.8 ± 1.4 | 4.9 ± 1.4 | 2.8 ± 0.5 | 3.8 ± 1.1 | 4.5 ± 1.4 | |
| PaO2 (kPa) | T = 0 | 36 ± 5 | 36 ± 3 | 37 ± 5 | 38 ± 4 | 40 ± 2 | 36 ± 4 |
| T = 4 | 40 ± 4 | 53 ± 3a | 44 ± 8 | 41 ± 2 | 48 ± 2b | 32 ± 16 | |
| HCO−3 (mmol/l) | T = 0 | 24 ± 4 | 23 ± 4 | 22 ± 3 | 23 ± 3 | 23 ± 2 | 22 ± 2 |
| T = 4 | 21 ± 4 | 21 ± 3 | 20 ± 2 | 16 ± 2 | 18 ± 3 | 22 ± 3 | |
| Respiratory rate | T = 0 | 35 ± 0 | 35 ± 0 | 35 ± 0 | 35 ± 0 | 35 ± 0 | 35 ± 0 |
| T = 4 | 36 ± 2 | 35 ± 0 | 35 ± 0 | 21 ± 2 | 16 ± 1b | 18 ± 1 | |
| End-tidal CO2 | T = 0 | 5.1 ± 0.9 | 5.2 ± 1.0 | 3.8 ± 1.2 | 4.0 ± 1.0 | 4.8 ± 1.0 | 3.1 ± 0.9 |
| T = 4 | 5.6 ± 1.2 | 3.3 ± 0.5a | 3.2 ± 1.5c | 2.6 ± 1.4 | 3.4 ± 1.0 | 2.0 ± 0.2 | |
Data are means ± SD. LP lung-protective mechanical ventilation
aLP saline versus LP + NaHS
bVILI saline versus VILI + NaHS
cLP saline versus LP + hypothermia