Table 2.
Effect of hydrogen sulfide donor NaHS and induced hypothermia on cell influx and protein concentrations in bronchoalveolar lavage fluid, pulmonary wet weight, and lung pathology scores in ventilator-induced lung injury (VILI)
| LP | VILI | |||||
|---|---|---|---|---|---|---|
| Saline | NaHS | Hypothermia | Saline | NaHS | Hypothermia | |
| Lung wet weight (mg) | 750 ± 116 | 784 ± 111 | 669 ± 101 | 967 ± 82a | 896 ± 117 | 1,206 ± 309 |
| Cell count (×104 cells/ml) | 13.4 ± 13 | 23.3 ± 21 | 35.6 ± 10 | 83.9 ± 47.9a | 41.7 ± 40 | 129 ± 149 |
| Protein (μg/ml) | 274 ± 185 | 373 ± 88.4 | 341 ± 186 | 658 ± 26a | 448 ± 174 | 769 ± 355 |
| Pathology score | 1.3 ± 1.0 | 2.0 ± 0.9 | 1.1 ± 0.4 | 4.2 ± 1.0a | 2.8 ± 0.8b | 3.6 ± 1.1 |
Data are means ± SD. LP lung-protective mechanical ventilation
aLP saline versus VILI saline
bVILI saline versus VILI + NaHS