Table 3.

Different Reported Approaches of Vascularizing Hepatocytes and Microfluidic Vascular Networks for Liver Tissue Engineering are Compared

Author	Concept	Design
Biomimetic vascular network	Microfluidic vascular network with adjacent hepatocytes separated by porous membrane	Biomimetic radial design with physiologic shear stress and 1:1 aspect ratio of all channels
Carraro et al.8	Microfluidic vascular network with adjacent hepatocytes separated by porous membrane	Linear network with multiple parallel capillary like beds, variable aspect ratio
Park et al.10	Microfluidic channels with hepatocytes and fibroblasts exposed to direct flow	Radial pattern of straight channels containing hepatocytes exposed to very low shear stress
Janakiraman et al.12	Microfluidic vascular network with adjacent porous material, optimized for nutrient transport	Multiple generation bifurcation design with large width:height aspect ratio for high planar diffusion of nutrients
Gilbert et al.11	Microfluidic vascular network with interconnected channels	Open network with diamond-shaped posts with high aspect ratio (>10:1 width:height)
McGuigan and Sefton44	Modules of hepatocytes suspended in collagen gel, coated with endothelial cells	Modules suspended in tube and form interconnected network of channels that can support perfusion