The effect of various applied patterns on bone fill in register to applied pattern. Treatment groups were defects with unfilled (Defect Control, n = 20), paired nonprinted (NP) DermaMatrix disks (NP Control, n = 10), NP control (n = 20) adjacent to BMP-2 (100 μg/mL BMP-2, 12 OPs, n = 20) pairs, and noggin (100 μg/mL BMP-2, 12 OPs, n = 18) adjacent to BMP-2 (n = 18). Animals were sacrificed after 4 weeks and evaluated by radiography. Data are presented as mean percentage of pattern fill ± standard error of the mean.