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. 2010 Feb 1;16(4):1443–1455. doi: 10.1089/ten.tea.2009.0343

FIG. 8.

FIG. 8.

Chondrogenic differentiation of annulus fibrosus cells pretreated with reversine in alginate beads. RT-PCR analysis of control and reversine-treated (50–300 nM) cells maintained in alginate culture under chondrogenic conditions. Note that there is upregulation in expression of (A) collagen type II (COL-II), (B) aggrecan (ACAN), (C) versican (VCAN), (D) collagen type IX, and (E) collagen type XI mRNA. Co: untreated cells maintained under chondrogenic conditions. *Significantly different from 50 nM reversine or control (Co); p < 0.05; data represent mean + SD of three independent experiments.