FIGURE 1.

Nucleotide and amino acid sequences of human SPINK6. A, schematic physical map of human SPINK gene loci (5q33.1). Genes are ordered from the centromere (left) to the telomere (right). B, schematic diagram of the SPINK6 gene based on its cDNA isolated from foreskin-derived keratinocytes. It consists of four exons and three introns. The positions of the exons (boxes) and introns (curve lines) of SPINK6 are deduced by comparing its full-length cDNA sequence with the corresponding genomic DNA. C, the two full-length SPINK6 cDNA sequences and the deduced protein sequence.