TABLE 2.

KLK inhibition by SPINK6

Values are the kinetic parameters of KLK interaction with recombinant SPINK6. Data include means ± S.E. of at least three replicates for each enzyme. NI, no inhibition.

Enzyme	Substrate	Km	Ki
		mm	nm
KLK5	Tosyl-Gly-Pro-Arg pNA	0.6 ± 0.06	1.33 ± 0.04
KLK7	MeO-Suc-Arg-Pro-Tyr pNA	2.0 ± 0.4	1070 ± 80
KLK8	Tosyl-Gly-Pro-Arg pNA	5.8 ± 0.8	NI
KLK14	Tosyl-Gly-Pro-Arg pNA	1.675 ± 0.27	0.5 ± 0.03