TABLE 2.

Amino acid sequence alignment of residues that form the conserved additional pocket of flavivirus MTases

AA indicates amino acid.

¹ All virus abbreviations used in the alignment are those of the International Committee on Taxonomy of Viruses. Abbreviations for mosquito-borne flaviviruses are as follows: West Nile virus (WNV); Chaoyang virus (CYV); Dengue virus serotype 1–4 (DENV1–4); Ilheus virus (ILHV); Japanese encephalitis virus (JEV); Lammi virus (LAMV); St. Louis encephalitis virus (SLEV); Zika virus (ZIKV); Aroa virus (AROAV); Bagaza virus (BAGV); Edge Hill virus (EHV); Kokobera virus (KOKV); Sepik virus (SEPV), Wesselsbron virus (WESSV); Banzi virus (BANV); Barkedji virus (BKV), Juga virus (JUGV); Yellow fever virus (YFV); Murray Valley encephalitis virus (MVEV); Usutu virus (USUV); Bouboui virus (BOUV); Nounané virus (NOUV); Potiskum virus (POTV); Saboya virus (SABV); Uganda virus (UGSV); Kedougou virus (KEDV). Abbreviations for tick-borne flaviviruses are as follows: Western, Siberian, and Far Eastern subtypes of the tick-borne encephalitis virus (WTBEV, STBEV, FETBEV); Loupig ill virus (LIV); Omsk hemorrhagic fever virus (OHFV); Greek goat encephalitis virus (GGEV); Gadgets Gully virus (GGYV); Karshi virus (KSIV); Langat virus (LGTV); Powassan virus (POWV); Royal Farm virus (RFV); Saumarez Reef virus (SREV); Spanish sheep encephalitis virus (SSEV); Turkish sheep encephalitis virus (TSEV); Tyuleniy virus (TYUV); Alkhurma hemorrhagic fever virus (AHFV); Kyasanur Forest disease virus (KFDV); Kadam virus (KADV); Meaban virus (MEAV). Abbreviations for tick-borne flaviviruses with no known arthropod vector are as follows: Montana myotis leukoencephalitis virus (MMLV); Aedes flavivirus (AEFV); Entebbe bat virus (ENTV); Nakiwogo virus (NAKV); Yokose virus (YOKV); Culex flavivirus (CFV); Kamiti River virus (KRV); Quang Binh virus (QBV); Cell fusing agent virus (CFAV); Rio Bravo virus (RBV); Modoc virus (MODV); Apoi virus (APOIV); and Tamana bat virus (TABV).