Table 2. PI3K/PTEN/AKT/mTOR pathway genotypes and toxicity.
| SNP and Genotype | Toxicity | ||||
|---|---|---|---|---|---|
| Yes | No | OR* | 95% CI | P value | |
| AKT1:rs3803304 | 62 | 93 | |||
| CC | 26 | 49 | 1.00 | ||
| CG | 30 | 37 | 1.43 | 0.71 to 2.86 | 0.317 |
| GG | 6 | 7 | 1.67 | 0.50 to 5.60 | 0.408 |
| CG + GG | 1.46 | 0.75 to 2.84 | 0.261 | ||
| AKT1:rs2494738 | 65 | 99 | |||
| AA | 53 | 81 | 1.00 | ||
| AG | 11 | 18 | |||
| GG | 1 | 0 | |||
| AG+GG | 1.04 | 0.45 to 2.42 | 0.921 | ||
| AKT1:rs2498804 | 66 | 97 | |||
| GG | 21 | 41 | 1.00 | ||
| GT | 37 | 46 | 1.45 | 0.71 to 2.95 | 0.305 |
| TT | 8 | 10 | 1.65 | 0.55 to 4.96 | 0.373 |
| GT + TT | 1.48 | 0.75 to 2.94 | 0.257 | ||
| AKT1:rs1130214 | 66 | 97 | |||
| GG | 30 | 54 | 1.00 | ||
| GT | 29 | 38 | 1.38 | 0.69 to 2.77 | 0.364 |
| TT | 7 | 5 | 2.92 | 0.80 to 10.67 | 0.105 |
| GT + TT | 1.55 | 0.79 to 3.01 | 0.200 | ||
| AKT2:rs892119 | 65 | 97 | |||
| AA | 40 | 72 | 1.00 | ||
| AG | 24 | 23 | 2.06 | 1.00 to 4.27 | 0.051 |
| GG | 1 | 2 | 1.00 | 0.08 to 12.26 | 1.000 |
| AG + GG | 1.97 | 0.97 to 4.02 | 0.061 | ||
| AKT2:rs8100018 | 63 | 95 | |||
| CC | 39 | 46 | 1.00 | ||
| CG | 20 | 39 | 0.54 | 0.26 to 1.12 | 0.096 |
| GG | 4 | 10 | 0.42 | 0.12 to 1.52 | 0.186 |
| CG + GG | 0.51 | 0.26 to 1.02 | 0.056 | ||
| FRAP1:rs11121704 | 66 | 97 | |||
| CC | 32 | 56 | 1.00 | ||
| CT | 28 | 36 | 1.31 | 0.65 to 2.62 | 0.448 |
| TT | 6 | 5 | 2.79 | 0.73 to 10.61 | 0.133 |
| CT + TT | 1.47 | 0.76 to 2.84 | 0.253 | ||
| FRAP1:rs2295080 | 66 | 98 | |||
| GG | 27 | 49 | 1.00 | ||
| GT | 32 | 42 | 1.40 | 0.71 to 2.76 | 0.333 |
| TT | 7 | 7 | 2.18 | 0.66 to 7.20 | 0.202 |
| GT + TT | 1.50 | 0.78 to 2.88 | 0.224 | ||
| PIK3CA:rs7651265 | 66 | 98 | |||
| AA | 58 | 76 | 1.00 | ||
| AG | 8 | 21 | |||
| GG | 0 | 1 | |||
| AG + GG | 0.43 | 0.17 to 1.06 | 0.065 | ||
| PIK3CA:rs7640662 | 65 | 99 | |||
| CC | 45 | 74 | 1.00 | ||
| CG | 17 | 24 | 1.05 | 0.49 to 2.25 | 0.909 |
| GG | 3 | 1 | 4.52 | 0.44 to 46.59 | 0.205 |
| CG + GG | 1.19 | 0.57 to 2.48 | 0.649 | ||
| PIK3CA:rs7621329 | 65 | 99 | |||
| CC | 47 | 63 | 1.00 | ||
| CT | 18 | 30 | |||
| TT | 0 | 6 | |||
| CT+TT | 0.63 | 0.31 to 1.28 | 0.202 | ||
| PIK3CA:rs6443624 | 66 | 99 | |||
| AA | 42 | 55 | 1.00 | ||
| AC | 24 | 36 | |||
| CC | 0 | 8 | |||
| AC + CC | 0.71 | 0.37 to 1.37 | 0.310 | ||
| PIK3CA:r52699887 | 65 | 98 | |||
| AA | 34 | 56 | 1.00 | ||
| AG | 21 | 38 | 0.93 | 0.46 to 1.89 | 0.845 |
| GG | 10 | 4 | 3.86 | 1.08 to 13.82 | 0.038 |
| AG + GG | 1.21 | 0.62 to 2.34 | 0.576 | ||
| PTEN:rs2299939 | 64 | 93 | |||
| AA | 51 | 58 | 1.00 | ||
| AC | 13 | 29 | |||
| CC | 0 | 6 | |||
| AC + CC | 0.44 | 0.20 to 0.95 | 0.036 | ||
| PTEN:rs12569998 | 66 | 99 | |||
| GG | 46 | 75 | 1.00 | ||
| GT | 19 | 23 | 1.40 | 0.66 to 2.97 | 0.386 |
| TT | 1 | 1 | 4.48 | 0.20 to 100.80 | 0.346 |
| GT + TT | 1.45 | 0.69 to 3.06 | 0.323 | ||
| PTEN:rs12357281 | 66 | 99 | |||
| CC | 61 | 86 | 1.00 | ||
| CG | 5 | 12 | |||
| GG | 0 | 1 | |||
| CG + GG | 0.54 | 0.17 to 1.66 | 0.281 | ||
*
adjusted for age, gender, clinical stage, performance status, and smoking status