Table 2.
Effect of a forty-day oral administration of Corrigiola telephiifolia root extract in rats.
| Dose of CT extracta (mg/kg) | Sex | D/Tb | Symptoms | Duration of symptoms |
|---|---|---|---|---|
| 0 | M | 0/8 | None | — |
| F | 0/8 | None | — | |
|
| ||||
| 5 | M | 0/8 | Slight abdominal contractionsc | — |
| F | 0/8 | Slight abdominal contractionsc | — | |
|
| ||||
| 70 | M | 0/8 | (i) Abdominal contractionsc | — |
| (ii) Hypoactivity, hunched posture, loss of appetite, mild diarrhea. | 1 week | |||
| (iii) Polyuria, yellow feces. | 5 weeks | |||
| F | 0/8 | (i) Abdominal contractionsc | — | |
| (ii) Hypoactivity, hunched posture, loss of appetite, mild diarrhea. | 2 weeks | |||
| (iii) Polyuria, yellow feces. | 5 weeks | |||
|
| ||||
| 2000 | M | 0/8 | (i) Abdominal contractionsc | — |
| (ii) Hypoactivity, hunched posture, loss of appetite, mild diarrhea. | 2-3 weeks | |||
| (iii) Polyuria, yellow feces | 5 weeks | |||
| F | 0/8 | (i) Abdominal contractionsc | — | |
| (ii) Marked hypoactivity, hunched posture, loss of appetite, intense diarrhea, | 4 weeks | |||
| (iii) Respiratory difficulties for 2 rats | 1 week | |||
| (iv) Polyuria, yellow feces | 5 weeks | |||
a C orrigiola telephiifolia extract was administered as a reiterated dose to groups of rats for forty days.
bD/T: dead /treated rats.
cThe abdominal contractions were noted only after the oral administration of the extract.