Table 2.

Acute NR-ANX-C pretreatment reduced EW-induced anxiety behavior in elevated plus maze.

Treatment group	Number of entries into		Total arm entries	% of open/total arm entries	Time spent in (s)		Number of rears in
	Open arms	Closed arms			Open arms	Closed arms	Open arms	Closed arms
EW control	2.3 ± 0.4	5.1 ± 0.9	7.1 ± 1.1	27.9 ± 5.4	18.6 ± 5.0	270.0 ± 5.5	1.4 ± 0.5	10.1 ± 1.4
Alprazolam (0.08 mg/kg)	6.2 ± 0.6**	7.3 ± 0.2	13.3 ± 0.7**	45.2 ± 2.3*	81.8 ± 12.5**	207.0 ± 18.5*	5.7 ± 0.8**	14.3 ± 1.0
NR-ANX-C (10 mg/kg)	1.8 ± 0.5	4.3 ± 0.9	6.2 ± 1.3	27.2 ± 5.6	29.0 ± 10.7	254.0 ± 12.9	1.7 ± 0.5	7.5 ± 0.7
NR-ANX-C (20 mg/kg)	2.7 ± 0.5	3.7 ± 0.8	6.3 ± 1.3	42.8 ± 4.2	56.0 ± 17.9	235.0 ± 18.5	2.3 ± 0.8	11.5 ± 1.7
NR-ANX-C (40 mg/kg)	7.0 ± 0.6**	8.0 ± 0.6*	15.0 ± 1.1**	48.2 ± 2.3**	73.8 ± 13.2*	215.0 ± 11.1*	8.7 ± 1.2**	13.0 ± 0.8

Values are mean ± SEM; Statistical analysis by One-way ANOVA followed by Dunnett's Multiple Comparison test. *P < .05; **P < .01.