Figure 6.

Effect of RN on the expression of ICAM-1 and HO-1 in lung tissue of OVA-induced rat model of asthma. Wistar rat lung tissue was obtained 24 hours after last Ova challenge. Immunohistochemistry was performed as described in materials and methods section. Expression of ICAM-1 and HO-1 in the lung tissues was scored as described in Section 2. Normal: rats sensitized with OVA and challenged with saline. Control: rats sensitized and challenged with OVA. DXM: OVA-sensitized and challenged rats treated with Dexamethasone (10 mg/kg). RN-1: OVA-sensitized and challenged rats treated with RN (0.25 g/kg/day). RN-2: OVA-sensitized and challenged rats treated with RN (0.5 g/kg/day). Data are expressed as mean ± S.E.M., n = 10 rats per group. ^▲▲▲ P < .01 versus Normal; ***P < .01 versus Control.