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. 2010 Sep 26;2011:765029. doi: 10.1155/2011/765029

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Copyright © 2011 Tulika Mishra et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Presumptive mechanism of apoptosis induction by ZMS. ZMS may affect the genes and transcription factors or may affect proteosome to induce apoptosis or may trigger some signals that directly change the mitochondrial permeability transition pore. This induces changes in the members of Bcl-2 family. It may interact with BAX (Bcl-2 associated X protein) and BAK (Bcl-2-proapoptotic member) and stimulate the release of cyt. C (Cytochrome C). Cytochrome C released from mitochondria binds to APAF-1 (Apoptotic protease activating factor-1) and procaspase-9 forming apoptosome and activating caspase-9 which in turn activates executor caspases (Caspase 3, 6, and 7) leading to cell death via apoptosis.