Table 3.

Results of Conditional Growth Curve Models: Effects of Inflammatory Markers on Estimates of Cognitive Function at Mean Age and Cognitive Decline

Measure and Inflammatory Marker	Inflammation Model*		Full Model†
	Intercept Effect	Slope Effect	Intercept Effect	Slope Effect
Abstraction
IL-6, pg/mL	−0.063‡	−0.002	0.003	0.000
CRP, mg/dL	−0.068‡	0.005	−0.050	0.004
Language
IL-6, pg/mL	−0.026‡	0.002	−0.009	0.001
CRP, mg/dL	−0.015	−0.001	−0.016	−0.001
Spatial ability
IL-6, pg/mL	−0.018	−0.001	0.016	0.001
CRP, mg/dL	−0.006	−0.006	−0.001	−0.006
Verbal recall
IL-6, pg/mL	−0.010	0.002	−0.001	0.001
CRP, mg/dL	−0.008	−0.006	−0.014	−0.005
Spatial recognition
IL-6, pg/mL	−0.004	−0.004	0.007	−0.001
CRP, mg/dL	−0.022	0.005	−0.019	0.008
Summary score
IL-6, pg/mL	−0.123‡	−0.001	0.016	0.004
CRP, mg/dL	−0.120	0.001	−0.102	0.003
SPMSQ
IL-6, pg/mL	0.001	−0.004	0.006	−0.003
CRP, mg/dL	−0.010	−0.002	−0.008	−0.001

Notes:

^*Inflammation model includes time, age, mortality indicator, practice effect, IL-6, and CRP.

^†Full model includes time, age, mortality indicator, practice effect, IL-6, CRP, female, black, education (y), income (> $10,000), diabetes, myocardial infarction, stroke, hip fracture, systolic and diastolic blood pressure, glycated hemoglobin, high-density lipoprotein cholesterol, waist circumference, non-steroidal antiinflammatory drug use, alcohol use in last month, physical activity, and smoking history.

^‡p <.05.

IL-6 = interleukin-6; CRP = C-reactive protein; SPMSQ = Short Portable Mental Status Questionnaire.