Table 4.

Results of Logistic Regression Models: Effects of High Inflammatory Markers on Risk of Being in the Bottom Tertile of Cognitive Decline (N = 533)

Cognitive test	Inflammation Model*	Full Model†
	OR (95% CI)	OR (95% CI)
Abstraction (≤−2)
IL-6 > 3.8 pg/mL	1.52 (1.01–2.27)	1.41 (0.92–2.15)
CRP > 2.7 mg/dL	0.74 (0.48–1.12)	0.75 (0.48–1.17)
Language (≤−1)
IL-6 > 3.8 pg/mL	1.36 (0.90–2.06)	1.31 (0.85–2.01)
CRP > 2.7 mg/dL	0.66 (0.43–1.02)	0.70 (0.44–1.11)
Spatial ability (≤−2)
IL-6 > 3.8 pg/mL	1.23 (0.82–1.84)	1.12 (0.73–1.70)
CRP > 2.7 mg/dL	1.23 (0.81–1.86)	1.35 (0.86–2.10)
Verbal recall (≤−2)
IL-6 > 3.8 pg/mL	1.29 (0.86–1.92)	1.32 (0.87–2.00)
CRP > 2.7 mg/dL	0.98 (0.65–1.48)	0.87 (0.56–1.35)
Spatial recognition (≤−4)
IL-6 > 3.8 pg/mL	0.96 (0.62–1.48)	0.96 (0.61–1.52)
CRP > 2.7 mg/dL	0.82 (0.52–1.28)	0.74 (0.45–1.19)
Summary score (≤−7)
IL-6 > 3.8 pg/mL	1.62 (1.07–2.45)	1.49 (0.97–2.28)
CRP > 2.7 mg/dL	0.74 (0.48–1.14)	0.72 (0.45–1.14)
SPMSQ decline (≤−2)
IL-6 > 3.8 pg/mL	1.88 (1.20–2.94)	1.67 (1.04–2.67)
CRP > 2.7 mg/dL	0.73 (0.45–1.19)	0.70 (0.41–1.16)

Notes:

^*Inflammation model includes age, IL-6, and CRP.

^†Full model includes age, IL-6, CRP, female, black, education (y), income (> $10,000), diabetes, myocardial infarction, stroke, hip fracture, systolic and diastolic blood pressure, glycated hemoglobin, high-density lipoprotein cholesterol, waist circumference, nonsteroidal antiinflammatory drug use, alcohol use in last month, physical activity, and smoking history.

OR = odds ratio; CI = confidence interval; IL-6 = interleukin-6; CRP = C-reactive protein; SPMSQ = Short Portable Mental Status Questionnaire.