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. 2010 Sep 27;6(6):569–583. doi: 10.7150/ijbs.6.569

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 5 — Embryonic lethality of Smad4^Co/Co;TTR-Cre embryos was rescued by fusion with wild type tetraploid embryos. (A,B) Contribution of tetraploid cells to extraembryonic tissues analyzed at E7.5 embryos by wholemount view (A) and histological sections (B). Arrows point tetraploid beta-gal positive cells that are generated from embryos of Rosa-26 mice after fusion. (C,D) Tetraploid embryos fused wild type (C) and Smad4^Co/Co;TTR-Cre (D) embryos at E11.5. (E) A rescued Smad4^Co/Co;TTR-Cre mutant mouse at birth.