Table 1.

Comparison of baseline intestinal cytokine and chemokine expression in 2-week-old mock control mice. The values are expressed as fold change and range in each strain compared to WT pups. NS-non-significant

Cytokine	TLR 2−/− (=10)	TLR 4−/− (n=10)	TLR 2−/−4−/− (n=10)	MR (n=10)	P value
IL-1α	0.26 (0.09–0.79)	0.35 (0.06–2.10)	0.15 (0.05–0.42)	0.28 (0.05–1.55)	NS
IL-2	0.48 (0.06–3.96)	0.78 (0.34–1.8)	0.15 (0.06–0.37)	0.30 (0.07–1.30)	NS
IL-4	1.20 (0.14–10.21)	0.46 (0.19–1.13)	0.32 (0.11–0.90)	2.06 (0.40–10.74)	NS
IL-6	1.18 (0.16–8.66)	1.30 (0.22–7.83)	0.10 (0.04–0.22)	2.41 (0.53–10.94)	NS
IL-10	0.68 (0.18–2.60)	0.31 (0.06–1.49)	0.14 (0.06–0.35)	4.41 (1.39–13.95)	NS
IL-17	2.22 (1.09–4.52)	2.32 (0.73–7.40)	1.62 (0.97–2.71)	3.14 (0.88–11.26)	NS
IL-22	3.70 (1.13–12.16)	1.82 (0.58–5.68)	1.40 (0.83–2.34)	3.72 (0.91–15.24)	NS
IL-23a	2.46 (0.55–11.04)	0.80 (0.10–6.36)	0.18 (0.05–0.66)	21.35 (4.02–113.39)*	*p<0.05
IFN-γ	1.92 (0.84–4.39)	1.96 (0.52–7.40)	1.49 (0.82–2.70)	15.88 (1.93–130.50)*	*p<0.05
TGF-β	0.65 (0.08–5.43)	0.29 (0.05–1.75)	0.32 (0.07–1.51)	0.41 (0.10–1.72)	NS
TNF-α	0.45 (0.27–0.73)	0.51 (0.11–2.28)	0.37 (0.15–0.95)	0.68 (0.22–2.08)	NS
LIX	0.45 (0.27–0.73)	0.46 (0.08–2.63)	0.27 (0.10–0.73)	1.99 (0.70–5.65)	NS
KC	0.49 (0.08–3.0)	1.14 (0.30–4.36)	0.09 (0.02–0.52)	3.83 (0.93–15.79)	NS
MIP-2	1.46 (0.89–2.39)	0.33 (0.05–2.14)	0.14 (0.01–1.28)	0.45 (0.04–4.63)	NS
Lungkine	0.87 (0.31–2.43)	0.30 (0.11–0.81)	0.14 (0.05–0.36)	0.34 (0.06–2.50)	NS
MPO	3.53 (2.18–5.69)	1.10 (0.37–3.32)	0.63 (0.40–1.01)	8.94 (3.35–23.85)*	*p<0.05