TABLE III.
Statistical Analysis of SNP.
| Gene Symbol (Location) | SNP | Chr | Position in Base Pairs From Chr Start | Alleles | HWE P Value* | OR (CI) | OR P Value |
|---|---|---|---|---|---|---|---|
| IL-10 (−592) | rs1800895 | 1 | 205013095 | A/G | .87 | † | † |
| IL-10 (−819) | rs1800894 | 1 | 205013289 | A/G | .0009 | † | † |
| IL-10 (−1082) | rs1800896 | 1 | 205013520 | A/G | .64 | † | † |
| IL-1α (+4845) | rs17561 | 2 | 113253694 | G/T | .51 | † | † |
| IL-1α (−819) | rs3783521 | 2 | 113260048 | C/T | .38 | † | † |
| IL-β (+3935) | rs1143634 | 2 | 113306861 | C/T | .73 | † | † |
| IL-β (−511) | rs3087258 | 2 | 113311342 | C/T | .0001 | † | † |
| CD14 (−159) | rs2569190 | 5 | 139993100 | A/G | .16 | † | † |
| TNF-α (−308) | rs1800629 | 6 | 31651010 | A‡/G | .93 | 1.86 (1.14,3.09)§ | .01 |
| IL-6 (−174) | rs13447445 | 7 | 22733281 | C/G | ‖ | † | † |
| IFNγ (−874) | rs2430561 | 12 | 66838789 | A/T | .71 | † | † |
| CCL2 (−2518) | rs3917882 | 17 | 29603912 | A/G | .93 | † | † |
| CCL5 (−403) | rs2107538 | 17 | 31231893 | C/T | .81 | † | † |
| TGF-β1 (509) | rs11466315 | 19 | 46551616 | C/G | .86 | † | † |
SNP = single-nucleotide polymorphism; Chr = chromosome; HWE = Hardy Weinberg equilibrium; OR = odds ratio; CI = confidence interval; rs = reference SNP; IL = interleukin; TNF = tumor necrosis factor; IFN = interferon; TGF = transforming growth factor; CCL = cysteinyl chemokine ligand.
*
Fisher exact test P values for tests of Hardy Weinberg equilibrium proportions in controls.
†
Confidence interval includes 1.00/P values not significant.
‡
Risk allele.
§
Dominant genetic model.
‖
SNP is monomorphic.