Table 2.
Final multivariate logistic regression model (polytomous) of HPV cofactors among women enrolled in SUCCEED restricted to women infected with (i) any HPV type, (ii) oncogenic-HPV types, (iii) HPV16 only, (iv) HPV16 or -18, (v) oncogenic HPV types excluding HPV16 and HPV18. Final models include all variables listed and age (quintiles) for comparisons of: (a) CIN3 compared to <CIN2, and (b) CIN2 compared to <CIN2.
| Characteristic | CIN3 v <CIN2 | CIN2 v <CIN2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All HPV OR (95% CI) |
Oncogenic HPV OR (95% CI) |
HPV16 OR (95% CI) |
HPV16 or 18 OR (95% CI) |
Non-HPV16, 18 OR (95% CI) |
All HPV OR (95% CI) |
Oncogenic HPV OR (95% CI) |
HPV16 OR (95% CI) |
HPV16 or 18 OR (95% CI) |
Non-HPV16, 18 OR (95% CI) |
|
| Race | ||||||||||
| White | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| Black | 0.6 (0.3–1.0) | 0.7 (0.4–1.1) | 0.9 (0.4–2.1) | 1.0 (0.4–2.1) | 0.9 (0.4–2.1) | 0.8 (0.5–1.2) | 0.9 (0.6–1.3) | 1.5 (0.7–3.1) | 1.6 (0.8–3.1) | 0.7 (0.4–1.3) |
| Other | 0.9 (0.5–1.5) | 0.9 (0.6–1.6) | 1.1 (0.5–2.4) | 1.1 (0.5–2.2) | 0.7 (0.2–2.3) | 1.1 (0.7–1.8) | 1.2 (0.7–1.8) | 1.2 (0.5–2.7) | 1.0 (0.5–2.2) | 1.4 (0.7–2.6) |
| Income ($) | ||||||||||
| <10,000 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 10,001–40,000 | 1.2 (0.9–1.7) | 1.3 (0.9–1.8) | 1.6 (1.0–2.6) | 1.5 (1.0–2.4) | 1.0 (0.6–2.0) | 1.2 (0.9–1.6) | 1.2 (0.9–1.7) | 1.9 (1.1–3.0) | 1.6 (1.0–2.4) | 0.9 (0.6–1.4) |
| 40,000+ | 1.9 (1.0–3.6) | 2.0 (1.0–3.8) | 2.4 (0.9–6.5) | 2.0 (0.8–4.9) | 3.9 (1.2–12.6) | 1.3 (0.7–2.4) | 1.3 (0.7–2.5) | 2.6 (1.0–7.2) | 2.3 (0.9–5.7) | 0.8 (0.3–2.1) |
| Lifetime number of sexual partners | ||||||||||
| 1 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 2–3 | 1.1 (0.6–2.3) | 1.1 (0.5–2.3) | 2.9 (0.9–9.2) | 2.2 (0.7–6.3) | 0.3 (0.1–1.0) | 1.6 (0.9–2.9) | 1.5 (0.8–2.9) | 2.2 (0.7–6.7) | 1.9 (0.7–5.3) | 1.2 (0.5–2.8) |
| 4–10 | 1.4 (0.7–2.7) | 1.3 (0.7–2.6) | 2.6 (0.9–7.8) | 1.9 (0.7–5.4) | 0.6 (0.2–1.7) | 1.5 (0.8–2.7) | 1.4 (0.8–2.7) | 1.9 (0.7–5.6) | 1.6 (0.6–4.3) | 1.1 (0.5–2.7) |
| 11+ | 1.4 (0.7–2.8) | 1.4 (0.6–2.9) | 2.8 (0.8–8.9) | 1.7 (0.6–5.1) | 0.7 (0.2–2.2) | 1.2 (0.6–2.3) | 1.1 (0.5–2.2) | 1.2 (0.4–3.9) | 0.9 (0.3–2.6) | 1.2 (0.5–3.1) |
| Number of pregnancies | ||||||||||
| 0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–3 | 1.6 (1.1–2.3) | 1.5 (1.0–2.3) | 1.2 (0.7–2.1) | 1.2 (0.7–1.9) | 3.2 (1.2–8.4) | 1.0 (0.8–1.4) | 1.0 (0.7–1.3) | 0.7 (0.4–1.3) | 0.8 (0.5–1.3) | 1.1 (0.7–1.9) |
| 4+ | 2.1 (1.3–3.6) | 2.0 (1.2–3.3) | 1.7 (0.8–3.6) | 1.7 (0.9–3.4) | 3.3 (1.1–10.2) | 1.1 (0.7–1.8) | 0.9 (0.5–1.5) | 0.7 (0.3–1.6) | 0.7 (0.3–1.5) | 1.3 (0.6–2.7) |
| Smoking | ||||||||||
| Never | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| Current | 2.5 (1.8–3.6) | 2.5 (1.8–3.6) | 2.7 (1.6–4.6) | 2.9 (1.8–4.7) | 2.0 (1.0–3.8) | 1.3 (0.9–1.7) | 1.3 (0.9–1.8) | 1.9 (1.1–3.2) | 1.7 (1.1–2.8) | 1.0 (0.6–1.5) |
| Former | 1.4 (0.9–2.3) | 1.5 (0.9–2.4) | 1.6 (0.8–3.2) | 1.8 (0.9–3.4) | 1.4 (0.6–3.4) | 0.8 (0.5–1.2) | 0.8 (0.5–1.3) | 0.8 (0.3–1.8) | 0.9 (0.4–1.9) | 0.8 (0.4–1.4) |
| Oral contraceptive use | ||||||||||
| Never | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| Ever | 1.1 (0.7–1.6) | 1.1 (0.7–1.7) | 0.9 (0.5–1.7) | 1.0 (0.6–1.8) | 2.0 (0.7–6.1) | 1.0 (0.7–1.5) | 1.1 (0.7–1.6) | 1.4 (0.7–2.8) | 1.7 (0.9–3.2) | 0.7 (0.4–1.3) |
| BMI | ||||||||||
| 20–<25 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 25–<30 | 1.4 (0.9–2.0) | 1.4 (0.9–2.1) | 1.5 (0.9–2.7) | 1.5 (0.9–2.4) | 1.7 (0.8–3.5) | 0.9 (0.6–1.2) | 0.8 (0.6–1.2) | 1.0 (0.6–1.8) | 1.1 (0.7–1.8) | 0.6 (0.4–1.1) |
| 30+ | 1.5 (1.0–2.2) | 1.6 (1.1–2.3) | 1.6 (0.9–2.7) | 1.5 (0.9–2.6) | 2.0 (1.0–4.2) | 0.8 (0.6–1.1) | 0.8 (0.6–1.2) | 0.7 (0.4–1.4) | 0.8 (0.5–1.4) | 0.7 (0.4–1.2) |
| <20 | 2.0 (1.3–3.1) | 2.0 (1.3–3.2) | 2.3 (1.2–4.3) | 2.5 (1.4–4.6) | 1.3 (0.5–3.7) | 1.1 (0.7–1.7) | 1.2 (0.8–1.8) | 1.2 (0.6–2.3) | 1.4 (0.8–2.7) | 0.9 (0.5–1.8) |